MLLT1 抗体 (AA 414-472)
Quick Overview for MLLT1 抗体 (AA 414-472) (ABIN1721516)
抗原
See all MLLT1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 414-472
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特异性
- Reacts with human ENL.
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纯化方法
- Purified (protein G)
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免疫原
- Maltose-binding fusion protein containing ENL amino acids 414-472 (Accession no. NP_005925).
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亚型
- IgG1
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anti-MLLT1, super elongation complex subunit (MLLT1) (AA 1-559) antibody
MLLT1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-MLLT1, super elongation complex subunit (MLLT1) (AA 472-559) antibodyMLLT1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3H2 unconjugated
anti-MLLT1, super elongation complex subunit (MLLT1) (AA 523-552), (C-Term) antibodyMLLT1 适用: 人 WB 宿主: 兔 Polyclonal RB1927-1928 unconjugated
anti-MLLT1, super elongation complex subunit (MLLT1) (AA 357-406) antibodyMLLT1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB(1 - 5 μg/mL) -
限制
- 仅限研究用
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缓冲液
- PBS, pH 7.4.
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注意事项
- Dilute in PBS or medium that is identical to that used in the assay system.
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储存条件
- -20 °C
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储存方法
- Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
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有效期
- 12 months
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- MLLT1 (MLLT1, super elongation complex subunit (MLLT1))
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别名
- ENL
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背景
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The AF4 and ENL (Eleven nineteen Leukemia) protein families are the most frequent MLL fusion partners accounting for two-thirds of MLL-associated leukemia incidence. The ENL family includes ENL and AF9 and has structural homology to the yeast Anc1 protein. ENL is a nuclear protein that is capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells as well as in yeast. Deletion muta-genesis demonstrated that the minimal portion of ENL required for activation of transcription was localized to its C-terminal 90 amino acids. This region is highly conserved between ENL and AF9 and is retained in all Hrx-ENL and Hrx-AF9 fusion proteins. Thus, the leukemogenic contribution and transcriptional activation potential of ENL colocalize to its highly conserved carboxy terminus.
Protein ENL YEATS domain-containing protein 1 LTG19 YEATS1 Gene name : MLLT1 -
基因ID
- 4298
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UniProt
- Q03111
抗原
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